Multi-omics

Single-cell genome-plus-transcriptome sequencing without upfront genome preamplification reveals differential cell state plasticity and treatment response between genetic subclones

Single-cell sequencing techniques allow the study of the subclonal architecture of tumours and reveal the co-occurrence of (driver) mutations as well as their order of acquisition over molecular pseudo-time. The development of multi-omics techniques …

Single-cell genome-plus-transcriptome sequencing without upfront genome preamplification reveals differential cell state plasticity and treatment response between genetic subclones

Single-cell sequencing techniques allow the study of the subclonal architecture of tumours and reveal the co-occurrence of (driver) mutations as well as their order of acquisition over molecular pseudo-time. The development of multi-omics techniques …

The magic behing Genome-and-Transcriptome (G&T) Sequencing

Short introduction and general review of single-cell multi-omics techniques developed by the research groups of Professor Voet

Single-Cell Multi-Omics Sequencing to Understand the Nature, Extent and Biology of Cellular Heterogeneity in Six Special Breast Cancer Cases

Breast tumors consist of different subpopulations of cells with potentially distinctive properties such as treatment-resistance or metastatic potential. Bulk sequencing methodologies have limited capacity to disclose the full extent, nature and …

Single-cell multi-omics to detect genetic variants in cancer and development

Short introduction and general review of single-cell multi-omics techniques developed by the research groups of Professor Voet

Single-cell multi-omics sequencing to understand the nature, extent and biology of cellular heterogeneity in breast cancer

Breast cancer tumors consist of different subpopulations of cells with potentially distinctive properties such as treatment-resistance and metastatic potential. Bulk sequencing methodologies have limited capacity to disclose the full extent, nature …

Single-cell multi-omics sequencing to understand the nature, extent and biology of cellular heterogeneity in breast cancer

Breast cancer tumors consist of different subpopulations of cells with potentially distinctive properties such as treatment-resistance and metastatic potential. Bulk sequencing methodologies have limited capacity to disclose the full extent, nature …

Single-cell multi-omics sequencing to understand the nature, extent and biology of cellular heterogeneity in breast cancer

Breast cancer tumors consist of different subpopulations of cells with potentially distinctive properties such as treatment-resistance and metastatic potential. Bulk sequencing methodologies have limited capacity to disclose the full extent, nature …